Neuron-specific knock-down of SMN1 causes neuron degeneration and death through an apoptotic mechanism
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چکیده
منابع مشابه
Neuron-specific knock-down of SMN1 causes neuron degeneration and death through an apoptotic mechanism
Spinal muscular atrophy is a devastating disease that is characterized by degeneration and death of a specific subclass of motor neurons in the anterior horn of the spinal cord. Although the gene responsible, survival motor neuron 1 (SMN1), was identified 20 years ago, it has proven difficult to investigate its effects in vivo. Consequently, a number of key questions regarding the molecular and...
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ژورنال
عنوان ژورنال: Human Molecular Genetics
سال: 2016
ISSN: 0964-6906,1460-2083
DOI: 10.1093/hmg/ddw119